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Category:
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Nuclear Receptors VDR-like Receptors
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Cat.No.
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Product Name
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2551 |
Calcitriol
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| Alternative name(s): |
1,25-Dihydroxyvitamin
D3 |
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Price and Availability
Click here for full price details of
Calcitriol
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Chemical Name:
(1a,3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,2
5-triol |
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Biological Activity:
Active metabolite of vitamin D3
that activates the vitamin D receptor (VDR). Displays calcaemic actions;
stimulates intestinal and renal Ca2+ absorption and regulates bone
Ca2+ turnover. Exhibits antitumour activity; inhibits in vivo and in
vitro cell proliferation in a wide range of cells including breast, prostate,
colon, skin and brain carcinomas and myeloid leukaemia cells.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Canalejo et al (2000) The in vitro effect of calcitriol on
parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11
1865. Beer and Myrthue (2004) Calcitriol in cancer treatment: from the
lab to the clinic. Mol.Cancer Ther. 3 373. Nijenhuis et
al (2006) The novel vitamin D analog ZK191784 as an intestine-specific
vitamin D antagonist. FASEB J. 20 1589.
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View related products by Pharmacological Action
or by Research Area
Keywords: Calcitriol, VDR-like Receptors, Vitamin D Receptor (VDR) Agonist, 1,25-Dihydroxyvitamin D3, Tocris Bioscience
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| “Our laboratory loves dealing with Tocris and consider many of the compounds you sell to be far better quality than the compounds that we have received from other companies. Once again, thank you very much..” Researcher, Albany Medical College, USA |
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