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Category:
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Nuclear Receptors VDR-like Receptors
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Cat.No.
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Product Name
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2700 |
Calcipotriol
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| Alternative name(s): |
MC 903 |
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Price and Availability
Click here for full price details of
Calcipotriol
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Chemical Name:
(1a,3b,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7
,10(19),22-tetraene-1,3,24-triol |
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Biological Activity:
Vitamin D3 analogue that
displays minimal effects on calcium homeostasis. Regulates cell differentiation
and proliferation; exhibits antiproliferative activity against human HL-60,
HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Binderup
(1993) Comparison of calcipotriol with selected metabolites and analogues of
vitamin D3: effects on cell growth regulation in vitro and calcium
metabolism in vivo. Pharmacol.Toxicol. 72 240. Knutson et
al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin
D2 in rats. Biochem.Pharmacol. 53 829. Wietrzyk
et al (2007) Antitumor properties of diastereomeric and geometric
analogs of vitamin D3. Anticancer Drugs 18 447.
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View related products by Pharmacological Action
or by Research Area
Keywords: Calcipotriol, VDR-like Receptors, Vitamin D3 Analogue, MC 903, Tocris Bioscience
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| “Our laboratory loves dealing with Tocris and consider many of the compounds you sell to be far better quality than the compounds that we have received from other companies. Once again, thank you very much..” Researcher, Albany Medical College, USA |
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