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Category:
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7TM Receptors Dopamine ReceptorsD2-like ReceptorsAgonists
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Cat.No.
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Product Name
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2664 |
Cabergoline
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Price and Availability
Click here for full price details of
Cabergoline
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Chemical Name:
N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-
(2-propenyl)ergoline-8-carboxamide |
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Biological Activity:
Selective D2-like
dopamine receptor agonist (Ki values are 0.7, 1.5, 9.0 and 165 nM
for D2, D3, D4 and D5 receptors
respectively) that also displays high affinity for several serotonin receptor
subtypes (Ki = 1.2-20.0 nM for 5-HT1A, 5-HT1D,
5-HT2A and 5-HT2B). Inhibits secretion of prolactin and
growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian
monkeys.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Eguchi et
al (1995) Effect of cabergoline, a dopamine agonist, on estrogen-induced
rat pituitary tumors:in vitro culture studies. Endocr.J. 42 413. Hadj
Tahar et al (2000) Sustained cabergoline treatment reverses
levodopa-induced dyskinesias in parkinsonian monkeys. Cin.Neuropharmacol. 23
195. Kvernmo et al (2006) A review of the receptor-binding and
pharmacokinetic properties of dopamine agonists. Clin.Ther. 28
1065.
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or by Research Area
Keywords: Cabergoline, Dopamine Receptors, Selective D2-like Agonist, Tocris Bioscience
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