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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowAMPA SelectivearrowOther
Cat.No. Product Name
2980 CX 546
Price and Availability

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CX 546
Chemical Name: (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethano ne

Biological Activity:

AMPA receptor potentiator. Binds specifically to the agonist bound nondesensitised receptor, most likely destabilising the desensitised receptor conformation. Enhances cognitive function in rats.

Technical Data:

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M.Wt: 247.29
Formula: C14H17NO3
Storage: Store at +4°C
Solubility: Soluble to 100 mM in DMSO and to 100 mM in Ethanol
Purity: >99%
CAS No: [215923-54-9]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Nagararjan et al (2001) Mechanism and impact of allosteric AMPA receptor modulation by the ampakineTM CX546. Neuropharmacol. 41 650. O'Neill et al (2004) AMPA receptor potentiators for the treatment of CNS disorders. Curr.Drug Targets CNS Neurol.Disord. 3 181. Shimazaki et al (2007) Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in  rats. Eur.J.Pharmacol. 575 94.
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    Keywords: CX 546, Ligand-gated Ion Channels, AMPA Receptor Potentiator, CX546, Tocris Bioscience
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