Chemical Name:(-)-cis-3-[2-Hydroxy-4-(1,1-dimethylheptyl)phenyl]-tran
s-4-(3-hydroxypropyl)cyclohexanol
Biological Activity:
Cannabinoid agonist which is
considerably more potent than Δ9-THC in both behavioural
tests and receptor binding assays. Displays high and roughly equal affinity for
both central and peripheral cannabinoid receptors (Ki = 0.6-5.0 and
0.7-2.6 nM at CB1 and CB2 receptors respectively).
Wiley et al (1995) Discriminative stimulus effects of CP 55,940 and
structurally dissimilar cannabinoids in rats. Neuropharmacology 34 669.
Gatleyet al (1997) Binding of the non-classical cannabinoid CP
55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors.
Life Sci. 61 191. Griffinet al (1998) Evaluation
of cannabinoid receptor agonists and antagonists using the guanosine-5¢-O-(3-[35S]thio)-triphosphate
binding assay in rat cerebellar membranes. J.Pharmacol.Exp.Ther. 285
553. Thomaset al (1998) Comparative receptor binding analyses of
cannabinoid agonists and antagonists. J.Pharmacol.Exp.Ther. 285
285.
Highly selective CB2 receptor agonist; Ki values are 0.037 and 363 nM for CB2 and CB1 receptors respectively. Increases P-ERK1/2 expression in HL-60 cells in vitro.
