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Category:
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Enzymes IsomerasesDNA Topoisomerase
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Cat.No.
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Product Name
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2688 |
CPT 11
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| Alternative name(s): |
Irinotecan |
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Camptothecin 11 |
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Price and Availability
Click here for full price details of
CPT 11
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Chemical Name:
(4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-d
ioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl
[1,4'-bipiperidine]-1'-carboxylic acid ester
hydrochloride |
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Biological Activity:
Inhibitor of DNA topoisomerase I that displays
antitumour activity against a range of tumour types.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Kawato et al
(1993) Inhibitory activity of camptothecin derivatives against
acetylcholinesterase in dogs and their binding activity to acetylcholine
receptors in rats. J.Pharm.Pharmacol. 45 444. Vassal et
al (1996) Therapeutic activity of CPT-11, a DNA topoisomerase I inhibitor
against peripheral primitive neuroectodermal tumour and neuroblastoma
xenografts. Br.J.Cancer. 74 537. Morton et al
(2005) Activation and antitumour activity of CPT-11 in plasma esterase-deficient
mice. Can.Chemother.Pharmacol. 56 629.
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or by Research Area
Keywords: CPT 11, Isomerases, DNA Topoisomerase I Inhibitor; Antitumour, Irinotecan, Camptothecin 11, CPT11, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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