CMPD1 | Kinases | Non-ATP-competitive P38a Inhibitor

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Category:

Enzymes

Kinases

MAPK

Cat.No.	Product Name
2186	CMPD-1

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CMPD1

Chemical Name: 2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanam ide

Biological Activity:

Non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (apparent K_i = 330 nM). Does not inhibit p38α-mediated phosphorylation of the two other known p38 substrates, MBP and ATF-2.

Technical Data:

M.Wt:	349.4
Formula:	C₂₂H₂₀FNO₂
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO and to 100 mM in Ethanol
Purity:	>99%
CAS No:	[41179-33-3]

Resources:

Certificate of Analysis / MSDS:

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References:

Davidson et al (2004) Discovery and Characterisation of a substrate selective p38α inhibitor. Biochemistry 43 11658.

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Keywords: CMPD1, Kinases, Non-ATP-competitive P38a Inhibitor, Tocris Bioscience

Literature in this Area

Scientific Reviews

Function & Modulation of MAP Kinase Pathways
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This accurate purity data is available on a batch-specific basis for every product via our website. At Tocris we work hard to ensure that we always supply to the highest possible standards of purity.

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CMPD-1

Biological Activity:

Technical Data:

Resources:

Certificate of Analysis / MSDS:

References: