CL 82198 | Proteases | Selective Inhibitor Of MMP-13 | CL82198

Category:

Cat.No.	Product Name
2632	CL 82198 hydrochloride

Price and Availability

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CL 82198

Chemical Name: N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride

Biological Activity:

Selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75.

Technical Data:

M.Wt:	338.83
Formula:	_{C17H33N2O3.HCl}
Storage:	Desiccate at RT
Solubility:	Soluble to 100 mM in Water and to 75 mM in DMSO
Purity:	>98%
CAS No:	[307002-71-7]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648. Borg et al (2003) IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75. Endocrine Abstr. 5 122.

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Keywords: CL 82198, Proteases, Selective Inhibitor Of MMP-13, CL82198, Tocris Bioscience

Literature in this Area

Signal Transduction Guide

	A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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Product Feature

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