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Category:
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Enzymes ReductasesDihydrofolate Reductase
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Cat.No.
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Product Name
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2039 |
CI 898 trihydrochloride
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| Alternative name(s): |
TMTX |
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Trimetrexate |
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Price and Availability
Click here for full price details of
CI 898 trihydrochloride
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Chemical Name:
5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-
quinazolinediamine trihydrochloride |
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Biological Activity:
Potent
lipophilic inhibitor of dihydrofolate reductase (DHFR) that displays
antineoplastic and antiprotozoal properties. Inhibits protozoal, bacterial and
human DHFR with IC50 values of 1.4, 6.1 and 3.2 nM respectively.
Affects G1/S phase cell cycle progression.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Hook et al
(1986) Cell cycle effects of trimetrexate (CI-898). Cancer Chemother.Pharmacol.
16 116. Allegra et al (1987) Potent in vitro and in vivo antitoxoplasma activity of the
lipid-soluble antifolate trimetrexate. J.Clin.Invest. 79 478. Chan
and Anderson (2006) Towards species-specific antifolates. Curr.Med.Chem. 13
377.
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Keywords: CI 898 Trihydrochloride, Reductases, Dihydrofolate Reductase Inhibitor, TMTX, Trimetrexate, CI898 Trihydrochloride, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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