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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowNMDA SitearrowAntagonists
Cat.No. Product Name
1241 CGS 19755
Price and Availability

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CGS 19755
Chemical Name: cis-4-[Phosphomethyl]-piperidine-2-carboxylic acid

Biological Activity:

Potent, competitive NMDA receptor antagonist. Anticonvulsant and neuroprotective.

Technical Data:

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M.Wt: 223.17
Formula: C7H14NO5P
Storage: Store at RT
Solubility: Soluble to 100 mM in Water and to 100 mM in DMSO
CAS No: [110347-85-8]

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    References:

    Lehmann et al (1988) CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. J.Pharmacol.Exp.Ther. 246 65. Bennett et al (1989) Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors. J.Pharmacol.Exp.Ther. 250 454. Perez-Pinzon et al (1995) Correlation of CGS 19755 neuroprotection against in vivo excitotoxicity and focal cerebral ischemia. J.Cereb.Blood Flow Metab. 15 865.
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    Keywords: CGS 19755, Ligand-gated Ion Channels, Potent, Competitive NMDA Antagonist, CGS19755, Tocris Bioscience
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