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Category:
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7TM Receptors Adenosine ReceptorsAntagonists
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Cat.No.
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Product Name
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2344 |
CGH 2466 dihydrochloride
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Price and Availability
Click here for full price details of
CGH 2466
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Chemical Name:
4-(3,4-Dichlorophenyl)-5-(4-pyridinyl)-2-thiazolamine
dihydrochloride |
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Biological Activity:
Adenosine
A1, A2B and A3 receptor antagonist (IC50
values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC50
= 187-400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). Displays
potent anti-inflammatory effects in vitro and in vivo. Potentially useful for
asthma and chronic obstructive pulmonary disease (COPD) research.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Trifilieff et al (2005) CGH2466, a
combined adenosine receptor antagonist, p38 mitogen-activated protein kinase
and phosphodiesterase type 4 inhibitor with potent in vitro and in
vivo anti-inflammatory activities. Br.J.Pharmacol. 144 1002.
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View related products by Pharmacological Action
or by Research Area
Keywords: CGH 2466, Adenosine Receptors, A1, A2B & A3 Antagonist & Inhibitor Of P38 MAPK & PDE4, CGH2466, Tocris Bioscience
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