|
Category:
|
Enzymes CyclaseGuanylyl Cyclase
|
|
Cat.No.
|
Product Name
|
|
2586 |
CFM 1571 hydrochloride
|
|
|
|
Price and Availability
Click here for full price details of
CFM 1571
|
|
Chemical Name:
3-[3-(Dimethylamino)propoxy]-N-(4-methoxyphenyl)-1-(phe
nylmethyl)-1H-pyrazole-5-carboxamide hydrochloride |
|
|
Biological Activity:
Soluble guanylyl cyclase (sGC) activator (EC50
= 5.49 μM).
Does not activate adenylyl cyclase, shows no significant inhibition of
phosphodiesterases and displays minimal inhibition of iNOS (25%) and nNOS
(17%). Inhibits collagen-stimulated platelet aggregation in vitro (IC50
= 2.84 μM).
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
|
References:
Selwood et al
(2001) Synthesis and biological evaluation of novel pyrazoles and indazoles as
activators of the nitric oxide receptor, soluble guanylate cyclase. J.Med.Chem.
44 78. Evgenov et al (2006) NO-independent
stimulators and activators of soluble guanylate cyclase: discovery and
therapeutic potential. Nat.Rev.Drug Discov. 5 755.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: CFM 1571, Cyclase, Soluble Guanylyl Cyclase (sGC) Inhibitor, CFM1571, Tocris Bioscience
|
|
Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
| “Our laboratory loves dealing with Tocris and consider many of the compounds you sell to be far better quality than the compounds that we have received from other companies. Once again, thank you very much..” Researcher, Albany Medical College, USA |
|
