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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowAcetylcholine (Nicotinic) ReceptorsarrowAntagonists
Cat.No. Product Name
2133 a-Bungarotoxin
Alternative name(s): a-Bgtx
a-BuTX
Price and Availability

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alpha-Bungarotoxin

Biological Activity:

Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM and > 3 μM respectively).

Technical Data:

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M.Wt: 7984.14
Formula: C338H529N97O105S11
Storage: Desiccate at -20°C
CAS No: [11032-79-4]

Resources:

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    References:

    Zhang et al (1994) Neuronal acetylcholine receptors that bind alpha-bungarotoxin with high affinity function as ligand-gated ion channels. Neuron 12 167. Lopez et al (1998) Unmasking the functions of the chromaffin cell α7 nicotinic receptor by using short pulses of acetylcholine and selective blockers. Proc.Natl.Acad.Sci.USA 95 14184.
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    Keywords: Alpha-Bungarotoxin, Ligand-gated Ion Channels, A7 Subtype-selective NAChR Antagonist, A-Bgtx, A-BuTX, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Nicotinic ACh Receptors
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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    Product Feature
    Nicotinic Receptors
    Key nicotinic receptor compounds now available from Tocris include:
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    Selective partial agonist at α4β2 receptors
    2303   PNU 282987
    Selective α7 nAChR agonist
    1029   Methyllycaconitine
    α7 neuronal nicotinic receptor antagonist
    View Product Feature
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