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Category:
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Enzymes KinasesProtein Kinase C
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Cat.No.
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Product Name
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2383 |
Bryostatin 1
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| Alternative name(s): |
NSC 339555 |
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Price and Availability
Click here for full price details of
Bryostatin 1
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Chemical Name:
(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Ac
etyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,
13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetrameth
yl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.11
1,15]nonacos-8-en-12-yl 2,4-octadie |
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Biological Activity:
Protein kinase C (PKC) activator that binds with
high affinity (Ki = 1.35 nM). Initially activates and subsequently
induces downregulation of PKC isozymes. Sensitises tumour cells to cytotoxic
effects of anticancer agents.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Lorenzo et al
(1997) The catalytic domain of protein kinase Cδ confers protection from
down-regulation induced by bryostatin 1. J.Biol.Chem. 272 33338. Wender
et al (1998) The design, computer modeling, solution structure, and
biological evaluation of synthetic analogs of bryostatin 1.
Proc.Natl.Acad.Sci.USA 95 6624. Sun and Alkon (2006)
Bryostatin-1: pharmacology and therapeutic potential as a CNS drug. CNS Drug
Rev. 12 1.
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View related products by Pharmacological Action
or by Research Area
Keywords: Bryostatin 1, Kinases, Protein Kinase C Activator, NSC 339555, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Product Feature
Kinase Inhibitors
Key kinase Inhibitors available from Tocris include:
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