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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowGABAA ReceptorsarrowAntagonists
Cat.No. Product Name
2503 (-)-Bicuculline methiodide
Price and Availability

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Bicuculline methiodide, (-)-
Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodi oxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[ 4,5-g]isoquinolinium iodide

Biological Activity:

Methiodide form of classical GABAA receptor antagonist (+)-bicuculline (Cat. No. 0130). More water-soluble and stable. Non-GABA receptor-mediated actions reported.

Technical Data:

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M.Wt: 509.3
Formula: C21H20INO6
Storage: Store at RT
Solubility: Soluble to 50 mM in Water
Purity: >99%
CAS No: [40709-69-1]

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    References:

    Olsen et al (1976) Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res. 102 283. Seutin and Johnson (1999) Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 20 268. Chan et al (2006) Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia. Diabetes 55 1080.
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    Keywords: Bicuculline Methiodide, (-)-, Ligand-gated Ion Channels, Water-soluble GABAA Antagonist, Bicuculline Methiodide,, Tocris Bioscience
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