Benazepril | Proteases | Angiotensin-converting Enzyme (ACE) Inhibitor | CGS 14824A

Category:

Enzymes

Proteases

Angiotensin-converting Enzyme

Cat.No.

Product Name

2578

Benazepril hydrochloride

Alternative name(s):

CGS 14824A

Benazepril C24H28N2O5.HCl (3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride

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Benazepril

Chemical Name: (3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]- 2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride

Biological Activity:

Non-peptide angiotensin-converting enzyme (ACE) inhibitor. Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.

Technical Data:

M.Wt:	460.96
Formula:	C₂₄H₂₈N₂O₅.HCl
Storage:	Desiccate at +4°C
Solubility:	Soluble to 50 mM in Water and to 100 mM in DMSO
Purity:	>99%
CAS No:	[86541-74-4]

Resources:

Certificate of Analysis / MSDS:

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References:

Takemori et al (1991) Effect of benazepril hydrochloride on cardiac hypertrophy in spontaneous hypertensive rats. Arzneim.-Forsch. 41 612. Ishibashi et al (1991) Hemodynamic effects of benazepril, an angiotensin-converting enzyme inhibitor, as studied in conscious normotensive dogs. Cardiovas. Drugs Ther. 5 635. Yamamoto et al (1991) General pharmacology of the novel angiotensin converting enzyme inhibitor benazepril hydrochloride. Effects on cardiovascular, visceral and renal functions and on hemodynamics. Arzneim.-Forsch. 41 913.

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Keywords: Benazepril, Proteases, Angiotensin-converting Enzyme (ACE) Inhibitor, CGS 14824A, Tocris Bioscience

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