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Category:
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7TM Receptors Cannabinoid ReceptorsNon-selective CB1/CB2
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Cat.No.
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Product Name
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2500 |
Bay 59-3074
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Price and Availability
Click here for full price details of
Bay 59-3074
Other Information:
Sold for
research purposes under agreement from Bayer
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Chemical Name:
3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl
4,4,4-trifluoro-1-butanesulfonic acid ester |
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Biological Activity:
Novel CB1/CB2 receptor
partial agonist (Ki values are 48.3 and 45.5 nM at human CB1 and
CB2 receptors respectively). Orally active CB1 agonist in
vivo. Displays anti-hyperalgesic and antiallodynic properties in rat models of
chronic neuropathic and inflammatory pain.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
De Vry et al
(2004)
3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate
(BAY 59-3074): a novel cannabinoid CB1/CB2 receptor
partial agonist with antihyperalgesic and antiallodynic effects.
J.Pharmacol.Exp.Ther. 310 620. De Vry et al (2004)
Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2
receptor partial agonist BAY 59-3074 in the rat. Eur J Pharmacol. 505
127.
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Keywords: Bay 59-3074, Cannabinoid Receptors, CB1 / CB2 Receptor Partial Agonist, Bay59-3074, Tocris Bioscience
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