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Category:
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7TM Receptors Peptides (Gastrointestinal)VIP Receptors
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Biological Activity:
Selective VPAC2 receptor agonist (IC50
values are 60, 8700 and > 10000 nM for VPAC2, VPAC1
and PAC1 receptors respectively) that potently stimulates cAMP
accumulation in human VPAC2 receptor transfected cells (EC50
values are 0.4, 100 and > 1000 nM for VPAC2, VPAC1 and
PAC1 respectively). Stimulates glucose-dependent insulin secretion
in isolated human pancreatic islets.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Tsutsumi et al
(2002) A potent and highly selective VPAC2 agonist enhances glucose-induced
insulin release and glucose disposal: a potential therapy for type 2 diabetes.
Diabetes 51 1453. Clairmont et al (2006)
Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase
IV stability and enhance in vivo glucose disposal. J.Med.Chem. 49
7545. Pan et al (2007) Engineering novel VPAC2-selective agonists
with improved stability and glucose-lowering activity in vivo.
J.Pharmacol.Exp.Ther. 320 900.
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View related products by Pharmacological Action
or by Research Area
Keywords: BAY 55-9837, Peptides (Gastrointestinal), Potent & Selective VPAC2 Agonist, BAY55-9837, Tocris Bioscience
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