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Category:
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7TM Receptors Glutamate (Metabotropic) ReceptorsGroup I mGlu ReceptorsAntagonists
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Cat.No.
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Product Name
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2501 |
Bay 36-7620
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Price and Availability
Click here for full price details of
Bay 36-7620
Other Information:
Sold for
research purposes under agreement from Bayer
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Chemical Name:
(3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethy
l)-1H-cyclopenta[c]furan-1-one |
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Biological Activity:
Selective mGlu1 receptor
non-competitive antagonist (IC50 = 0.16 μM) with
inverse agonist activity. Displays neuroprotective and anticonvulsive effects
in rats following systemic administration.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Carroll et al (2001) BAY36-7620: a potent non-competitive mGlu1
receptor antagonist with inverse agonist activity. Mol.Pharmacol. 59
965. De Vry et al (2001) Neuroprotective and behavioural effects
of the selective metabotropic glutamate mGlu1 receptor antagonist
BAY 36-7620. Eur.J.Pharmacol. 428 203. Lavreysen et al (2003)
[3H]R214127: a novel high-affinity radioligand for the mGlu1
receptor reveals a common binding site shared by multiple allosteric
antagonists. Mol.Pharmacol. 63 1082.
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Keywords: Bay 36-7620, Glutamate (Metabotropic) Receptors, Non-competitive MGlu1 Antagonist With Inverse Agonist Activity, Bay36-7620, Tocris Bioscience
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