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Category:
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Ion Channels Sodium ChannelsVoltage-gated Sodium Channels
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Cat.No.
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Product Name
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2914 |
Batrachotoxin
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Price and Availability
Click here for full price details of
Batrachotoxin
Other Information:
Conditions of supply may be associated with this item;
the relevent licence/documentation from the appropriate governing body will be
required. Please contact technicalsupport@tocris.co.uk for further information.
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Chemical Name:
(1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,
10,11,11a,12,13-Dodecahydro-9,12-dihydroxy-2-11a-dimeth
yl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-f][1,4]o
xazepin-14-yl]ethyl
2,4-dimethyl-1H-pyrrole-3-carboxylate |
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Biological Activity:
Potent neurotoxin that activates voltage- gated
sodium channels. Shifts voltage-dependent activation is shifted to more
negative potentials, inactivation is disabled and pore conductance and
selectivity are altered (displays increased permeability for NH4+,
K+ and Cs+ ions).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Li et al (2002) The
batrachotoxin receptor on the voltage-gated sodium channel is guarded by the
channel activation gate. Mol.Pharmacol. 61 905. Bosmans et
al (2004) The poison dart frog's batrachotoxin modulates NaV1.8.
FEBS Lett. 577 245. Wang et al (2006) How
batrachotocin modifies the sodium channel permeation pathway: computer modeling
and site-directed mutagenesis. Mol.Pharmacol. 69 788.
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View related products by Pharmacological Action
or by Research Area
Keywords: Batrachotoxin, Sodium Channels, Voltage-gated Na+ Channel Activator, BTX, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
| “Tocris is to be congratulated for continuing to meet the current demand for a rapid and reliable source of high-quality compounds that are urgently needed as pharmacological tools by a growing international population of cannabinoid researchers..” Researcher, University of Aberdeen, UK |
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