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Category:
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7TM Receptors Opioid ReceptorsDelta ReceptorsAgonists
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Cat.No.
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Product Name
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1663 |
BW 373U86
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Price and Availability
Click here for full price details of
BW 373U86
Other Information:
Sold for
research purposes under agreement from GlaxoSmithKline
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Chemical Name:
4-[(aR*)-a-((2S*,5R*)-4-Allyl-2,5-dimethyl-1-piperaziny
l)-3-hydroxybenzyl]-N,N-diethylbenzamide |
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Biological Activity:
Potent,
selective non-peptide δ-opioid receptor agonist. Ki
values are 1.8, 15 and 34 nM for δ, μ and κ receptors respectively. Centrally
active following systemic administration in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Chang et al (1993) A novel, potent
and selective nonpeptidic delta opioid receptor agonist BW373U86.
J.Pharmacol.Exp.Ther. 267 852. Dykstra et al (1993)
A novel delta opioid agonist, BW373U86, in squirrel monkeys responding under a
schedule of shock titration. J.Pharmacol.Exp.Ther. 267 875. Broom
et al (2002) Comparison of receptor mechanisms and efficacy requirements
for δ-agonist-induced
convulsive activity and antinociception in mice. J.Pharmacol.Exp.Ther. 303
723.
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or by Research Area
Keywords: BW 373U86, Opioid Receptors, Potent, Selective Non-peptide D-opioid Agonist, BW373U86, Tocris Bioscience
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