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Category:
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Enzymes PhosphatasesPTP
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Cat.No.
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Product Name
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2176 |
BVT 948
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Price and Availability
Click here for full price details of
BVT 948
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Chemical Name:
4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione |
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Biological Activity:
Non-competitive, cell-permeable
inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09-1.7 μM);
displays irreversible inhibition through catalysis of the hydrogen
peroxide-dependent oxidation of PTP. Enhances insulin signalling in vitro and
insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450
isoforms (IC50 < 10 μM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Liljebris et al (2004) Oxidation of protein tyrosine phosphatases as
a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione.
J.Pharmacol.Exp.Ther. 309 711.
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View related products by Pharmacological Action
or by Research Area
Keywords: BVT 948, Phosphatases, Non-competitive Protein Tyrosine Phosphatase Inhibitor; Enhances Insulin Signalling, BVT948, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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