BIBP 3226 | Peptides (Neuropeptides) | Mixed NPY Y1 & NPFF Receptor Antagonist

Category:

Cat.No.	Product Name
2707	BIBP 3226 trifluoroacetate

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BIBP 3226

Chemical Name: N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphen yl)methyl]amino]carbonyl]butyl-a-phenylbenzeneacetamide trifluoroacetate

Biological Activity:

Mixed non-peptide neuropeptide Y Y₁ (NPY Y₁) and neuropeptide FF (NPFF) receptor antagonist (K_i values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y₁, hNPFF₂, rNPFF, rNPY Y₂, rNPY Y₄ and rNPY Y₅ respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.

Technical Data:

M.Wt:	587.59
Formula:	C₂₇H₃₁N₅O₃.CF₃CO₂H
Storage:	Store at -20°C
Solubility:	Soluble to 10 mM in Water
Purity:	>98%
CAS No:	[159013-54-4]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Kask et al (1996) Anxiogenic-like effect of the neuropeptide Y Y₁ receptor antagonist BIBP3226: antagonism with diazepam. Eur.J.Pharmacol. 317 R3. Mollereau et al (2001) Agonist and antagonist activities on human NPFF₂ receptors of the NPY ligands GR231118 and BIBP3226. Br.J.Pharmacol. 133 1. Fang et al (2006) In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides 27 2207.

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Keywords: BIBP 3226, Peptides (Neuropeptides), Mixed NPY Y1 & NPFF Receptor Antagonist, Tocris Bioscience

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