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Category:
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7TM Receptors Peptides (Hypothalamic/Pituitary Hormones)CRF Receptors
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Biological Activity:
Potent and selective corticotropin-releasing
factor receptor 2 (CRF2) antagonist (Ki values are 1.3
and > 500 nM respectively). Antagonises CRF2-mediated inhibition
of gastric emptying.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Rivier et al
(2002) Potent and long-acting corticotropin releasing factor (CRF) receptor 2
selective peptide competitive antagonists. J.Med.Chem. 45 4737. Hoare
et al (2005) Peptide ligand binding properties of the
corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of
endogenously expressed receptors, G-protein-coupled sensitivity and
determinants of CRF2 receptor selectivity. Peptides 26
457. Henry et al (2006) The effect of lateral septum
corticotropin-releasing factor receptor 2 activation on anxiety is modulated by
stress. J.Neurosci. 26 9142.
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Keywords: Astressin 2B, Peptides (Hypothalamic / Pituitary Hormones), Selective CRF2 Antagonist, Tocris Bioscience
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