Astressin | Peptides (Hypothalamic / Pituitary Hormones) | Potent CRF Receptor Antagonist | [D-Phe12, Nle21,38, Glu30, Lys33]-CRF (12-41)

Category:

7TM Receptors

Peptides (Hypothalamic/Pituitary Hormones)

CRF Receptors

Cat.No.

Product Name

1606

Astressin

Alternative name(s):

[D-Phe¹², Nle^21,38, Glu³⁰, Lys³³]-CRF (12-41)

Price and Availability

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Astressin

Other Information:

Sold with the permission of the SALK Institute

Biological Activity:

Potent corticotropin-releasing factor (CRF) receptor antagonist (K_i values are 2, 1.5 and 1 nM at CRF₁, CRF₂_α and CRF₂_β). Reduces ACTH secretion, blocks delayed gastric emptying and is neuroprotective in vivo.

Technical Data:

M.Wt:	3563.2
Formula:	C₁₆₁H₂₆₉N₄₉O₄₂
Storage:	Desiccate at -20°C
CAS No:	[170809-51-5]

Resources:

Certificate of Analysis / MSDS:

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References:

Gulyas et al (1995) Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. Proc.Natl.Acad.Sci.USA 92 10575. Maecker et al (1997) Astressin, a novel and potent CRF antagonist, is neuroprotective in the hippocampus when administered after a seizure. Brain Res. 744 166. Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312. Martinez et al (1999) Peripheral injection of a new corticotropin-releasing factor (CRF) antagonist, astressin, blocks peripheral CRF- and abdominal surgery-induced delayed gastric emptying in rats. J.Pharmacol.Exp.Ther. 290 629.

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Keywords: Astressin, Peptides (Hypothalamic / Pituitary Hormones), Potent CRF Receptor Antagonist, [D-Phe12, Nle21,38, Glu30, Lys33]-CRF (12-41), Tocris Bioscience

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