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Category:
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Transporters Ion Pumps/Transporters
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Cat.No.
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Product Name
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2668 |
Artemisinin
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| Alternative name(s): |
Qinghaosu |
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Price and Availability
Click here for full price details of
Artemisinin
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Chemical Name:
(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3
,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-on
e |
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Biological Activity:
Antimalarial agent; interacts with haem to
produce carbon-centred free radicals, causes protein alkylation and damages
parasite microorganelles and membranes. Also selectively inhibits the P-type
ATPase (PfATP6) of Plasmodium falciparum (Ki ~ 150 nM). Displays
antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Balint (2001)
Artemisinin and its derivatives. An important new class of antimalarial agents.
Pharmacol.Ther. 90 261. Eckstein-Ludwig et al
(2003) Artemisinins target the SERCA of Plasmodium falciparum. Nature 424
957. Wartenberg et al (2003) The antimalarial agent artemisinin
exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid
bodies. Lab.Invest. 83 1647.
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View related products by Pharmacological Action
or by Research Area
Keywords: Artemisinin, Ion Pumps / Transporters, Antimalarial; Inhibits P-type ATPase (PfATP6) Of P. Falciparum, Qinghaosu, Tocris Bioscience
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