Apamin | Potassium Channels | K+ Channel Blocker (small Conductance, Ca2+-dependent)

Category:

Cat.No.	Product Name
1652	Apamin

Price and Availability

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Apamin

Biological Activity:

Prototypical potent and highly selective inhibitor of the small-conductance Ca²⁺-activated K⁺-channel (SK_Ca). Blocks medium after-hyperpolarisation in vitro and is brain penetrant and convulsive in vivo.

Technical Data:

M.Wt:	2027.34
Formula:	C₇₉H₁₃₁N₃₁O₂₄S₄
Storage:	Desiccate at -20°C
CAS No:	[24345-16-2]

Resources:

Certificate of Analysis / MSDS:

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References:

Habermann (1984) Apamin. Pharmac.Ther. 25 255. Strong (1990) Potassium channel toxins. Pharmac.Ther. 46 137. van der Staay et al (1999) Behavioral effects of apamin, a selective inhibitor of the SK_Ca-channel, in mice and rats. Neurosci.Biobehav.Rev. 23 1087. Stocker et al (2004) Matching molecules to function: neuronal Ca²⁺-activated K⁺ channels and afterhyperpolarizations. Toxicon 43 933.

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Keywords: Apamin, Potassium Channels, K+ Channel Blocker (small Conductance, Ca2+-dependent), Tocris Bioscience

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