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Anti-phospho-GluR1(Ser 831) unphosphoylated blocking peptide
Biological Activity:
Synthetic peptide (LIPQQSINEAI[K]) corresponding
to amino acids 826-836 of rat mature GluR1 (Accession No. P19490), with a
lysine added to the C-terminus for conjugation. Depletion peptide used during
purification of anti-phospho-GluR1 (Ser831) (Cat. No. 2041).
Displays 26-fold and > 440-fold selectivity over kainate and NMDA receptors respectively. Neuro-protective; delays neuronal death in a global ischaemia model and cerebral infarction in a focal ischaemia model.