Chemical Name:(2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidined
iol 3-acetate
Biological Activity:
Protein synthesis inhibitor (blocks translation). Potent activator
of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a
potent signalling agonist to selectively elicit homologous desensitisation of
immediate early gene induction (c-fos, fosB, c-jun, junB and junD).
Kyriakiset al (1994) The stress-activated protein kinase subfamily
of c-Jun kinases. Nature 369 156. Sanchezet al
(1994) Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating
transcription factor c-Jun. Nature 372 794. Canoet al
(1994) Anisomycin-activated protein kinases p45 and p55 but not
mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction
of c-fos and c-jun. Mol.Cell.Biol. 14 7352. Hazzalinet al (1998) Anisomycin selectively desensitizes signalling components
involved in stress kinase activation and fos and jun induction.
Mol.Cell.Biol. 18 1844.
