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Category:
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Ion Channels Calcium ChannelsVoltage-gated Calcium Channels
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Cat.No.
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Product Name
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2571 |
Amlodipine besylate
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| Alternative name(s): |
Norvasc |
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Price and Availability
Click here for full price details of
Amlodipine
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Chemical Name:
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydr
o-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl
5-methyl ester benzenesulfonate |
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Biological Activity:
L-type
calcium channel blocker that displays antihypertensive properties. Inhibits Ca2+-induced
contractions in depolarised rat aorta (IC50 = 1.9 nM) and displays
vasoprotective effects in cardiovascular disease. Inhibits proliferation of
human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50
= 25 μM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Burges et al (1987) Calcium channel
blocking properties of amlodipine in vascular smooth muscle and cardiac muscle
in vitro: evidence for voltage modulation of vascular dihydropyridine
receptors. J.Cardiovasc.Pharmacol. 9 110. Yoshida et al
(2003) Antiproliferative effect of Ca2+ channel blockers on human
epidermoid carcinoma A431 cells. Eur.J.Pharmacol. 472 23. Toba
et al (2005) Calcium channel blockades exhibit anti-inflammatory and
antioxidative effects by augmentation of endothelial nitric oxide synthase and
the inhibition of angiotensin converting enzyme in the NG-nitro-L-arginine methyl ester-induced hypertensive rat aorta:
vasoprotective effects beyond the blood pressure-lowering effects of amlodipine
and manidipine. Hypertens.Res. 28 689.
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View related products by Pharmacological Action
or by Research Area
Keywords: Amlodipine, Calcium Channels, Ca2+ Channel Blocker (L-type), Norvasc, Tocris Bioscience
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Literature in this Area Scientific Reviews
Mechanisms for Manipulating Intracellular Calcium Buffering Download PDF Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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