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Category: 7TM ReceptorsarrowDopamine ReceptorsarrowD2-like ReceptorsarrowAntagonists
Cat.No. Product Name
2132 Amisulpride
Alternative name(s): DAN 2163
Price and Availability

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Amisulpride
Chemical Name: 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulf onyl)-2-benzamide

Biological Activity:

Potent, selective dopamine D2 and D3 receptor antagonist. Ki values are 2.8 and 3.2 nM respectively for human D2 and D3 and > 1000 nM for human D1, D4 and D5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2/D3 receptors at higher doses. Preferentially interacts with limbic D2-like receptors in vivo. Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.

Technical Data:

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M.Wt: 369.48
Formula: C17H27N3O4S
Storage: Store at -20°C
Solubility: Soluble to 50 mM in 1eq. HCl and to 50 mM in DMSO
Purity: >98%
CAS No: [71675-85-9]

Resources:

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    • Certificate of Analysis / MSDS:

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    Product/Material Safety Data Sheet: View current batch

    References:

    Perrault et al (1997) Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 dopamine receptor antagonist activity and limbic selectivity. J.Pharmacol.Exp.Ther. 280 73. Schoemaker et al (1997) Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J.Pharmacol.Exp.Ther. 280 83. Moller (2003) Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality. Prog.Neuro-Psychopharm.Biol.Psychiat. 27 1101.
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    Keywords: Amisulpride, Dopamine Receptors, Selective D2 / D3 Receptor Antagonist; Atypical Antipsychotic Agent, DAN 2163, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Dopamine Receptors
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