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Tocris Bioscience
Category: EnzymesarrowPolymerasesarrowRNA/DNA Polymerase
Cat.No. Product Name
2513

Acyclovir

Alternative name(s): Aciclovir
Acycloguanosine

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Chemical Name: 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-puri n-6-one

Biological Activity:

Anti-viral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50 values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerisation through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).

Technical Data:

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M.Wt: 225.21
Formula: C8H11N5O3
Storage: Store at RT
Solubility: Soluble to 50 mM in 1eq. HCl and to 20 mM in DMSO
Purity: >99 %
CAS No: [59277-89-3]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch
Product/Material Safety Data Sheet: View current batch

References:

Elion et al (1977) Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc.Natl.Acad.Sci.USA. 74 5716. Hayashi et al (2006) The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy. J.Gene.Med. 8 1056. Suzuki et al (2006) Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 72 157.
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Keywords: Acyclovir, Polymerases, Inhibits Viral DNA Polymerase; Antiherpetic Agent, Tocris Bioscience
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