Actinomycin D | Polymerases | Inhibits RNA Polymerase

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Cat.No.	Product Name
1229	Actinomycin D

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Actinomycin D

Chemical Name: 2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5, 9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7 ,10,13] oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H- phenoxazine-1,9-dicarboxamide

Biological Activity:

Anti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.

Technical Data:

M.Wt:	1255.43
Formula:	C₆₂H₈₆N₁₂O₁₆
Storage:	Desiccate at +4°C
Solubility:	Soluble to 50 mM in DMSO
CAS No:	[50-76-0]

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References:

Aktipis et al (1981) A kinetic study on the mechanism of inhibition of RNA synthesis catalyzed by DNA-dependent RNA polymerase. Differences in inhibition by ethidium bromide, 3,8-diamino-6-ethylphenanthridinium bromide and actinomycin D. Biochim.Biophys.Acta 655 278. Glynn et al (1992) Apoptosis induced by actinomycin D, camptothecin or aphidicolin can occur in all phases of the cell cycle. Biochem.Soc.Trans. 20 84S. Jeeninga et al (1981) The mechanism of actinomycin D-mediated inhibition of HIV-1 reverse transcription. Nucleic Acids Res. 26 5472.

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Keywords: Actinomycin D, Polymerases, Inhibits RNA Polymerase, Tocris Bioscience

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