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Category:
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Ion Channels Sodium ChannelsVoltage-gated Sodium Channels
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Cat.No.
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Product Name
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2976 |
A 803467
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Price and Availability
Click here for full price details of
A 803467
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Chemical Name:
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarbo
xamide |
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Biological Activity:
Selective blocker of NaV1.8
channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8,
hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2
channels respectively). Shows no significant activity against TRPV1, P2X2/3,
CaV2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates
mechanical allodynia in two models of neuropathic pain following i.p.
administration.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Jarvis et
al (2007) A-803467, a potent and selective NaV1.8 sodium channel
blocker, attenuates neuropathic and inflammatory pain in the rat.
Proc.Natl.Acad.Sci. 104 8520. Rush and Cummins (2007)
Painful research: identification of a small-molecule inhibitor that selectively
targets NaV1.8 sodium channels. Mol.Interv. 7 192. McGaraughty
et al (2008) A selective NaV1.8 sodium channel blocker,
A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide],
attenuates spinal neuronal activity in neuropathic rats. J.Pharmacol.Exp.Ther. 324
1204.
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View related products by Pharmacological Action
or by Research Area
Keywords: A 803467, Sodium Channels, Selective NaV1.8 Blocker, A803467, Tocris Bioscience
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