|
Category:
|
Enzymes ProteasesCaspase
|
|
Cat.No.
|
Product Name
|
|
2172 |
AZ 10417808
|
| Alternative name(s): |
AQZ-1 |
|
|
Price and Availability
Click here for full price details of
AZ 10417808
Other Information:
Sold with
the permission of AstraZeneca UK Ltd
|
|
Chemical Name:
2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo
-N-2-propenyl-8-quinazolinecarboxamide |
|
|
Biological Activity:
Selective non-peptide inhibitor of caspase-3 (Ki
= 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki
> 10 μM).
Completely blocks staurosporine-induced intracellular DEVDase activity in
SH-SY5Y cells (IC50 = 14.9 μM).
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
|
|
|
References:
Scott et
al (2003) Novel small molecule inhibitors of caspase-3 block cellular and
biochemical features of apoptosis. J.Pharmacol.Exp.Ther. 304 433.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: AZ 10417808, Proteases, Selective Non-peptide Caspase-3 Inhibitor, AQZ-1, AZ10417808, Tocris Bioscience
|
|
Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Featured New Product
Dipeptidyl peptidase IV inhibitor
2783
DPPI 1c
Inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC50 > 30 μM). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.
View all Featured New Products
|
