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Category:
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Cellular Processes and Components Signal TransductionHedgehog Signalling
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Cat.No.
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Product Name
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1639 |
AY 9944 dihydrochloride
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Price and Availability
Click here for full price details of
AY 9944
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Chemical Name:
trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedime
thanamine dihydrochloride |
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Biological Activity:
Inhibitor
of hedgehog (hh) signalling, possibly via several mechanisms. Inhibits Δ7-dehydrocholesterol reductase, thus
reduces cholesterol biosynthesis, and also inhibits cholesterol esterification.
May also directly block the cellular response to hh proteins. Teratogenic in
vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Kraml et al (1964) Inhibition of
the conversion of 7-dehydrocholesterol to cholesterol by AY-9944.
Biochem.Biophys.Res.Comm. 15 455. Cooper et al
(1998) Teratogen-mediated inhibition of target tissue response to Shh
signaling. Science 280 1603. Incardona and Eaton (2000)
Cholesterol in signal transduction. Curr.Op.Cell Biol. 12 193.
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View related products by Pharmacological Action
or by Research Area
Keywords: AY 9944, Signal Transduction, Inhibitor Of Hedgehog (hh) Signalling. Inhibits D7-dehydrocholesterol Reductase, AY9944, Tocris Bioscience
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Literature in this Area Cancer Research Guide | Our unique collection of more than 300 products related to cancer research, including the very latest exclusive research tools. | | Request Copy / View PDF |
Purity To Rely On
When choosing reagents for an experiment, the prime consideration is often to obtain the highest quality products available.
Unlike other suppliers, our in-house QC team carry out multiple analytical tests to thoroughly assess the purity of our reagents before they are offered for sale.
This accurate purity data is available on a batch-specific basis for every product via our website. At Tocris we work hard to ensure that we always supply to the highest possible standards of purity.
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