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Category: EnzymesarrowProteasesarrowMMP
Cat.No. Product Name
2622 ARP 101
Price and Availability

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ARP 101
Chemical Name: (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)- 3-methylbutanamide

Biological Activity:

Selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively).

Technical Data:

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M.Wt: 406.5
Formula: C20H26N2O5S
Storage: Desiccate at +4°C
Solubility: Soluble to 100 mM in DMSO and to 25 mM in Ethanol
Purity: >99%

Resources:

    		•

    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Tuccinardi et al (2006) Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides. Bioorg.Med.Chem. 14 4260.
    View related products by Pharmacological Action or by Research Area

    Keywords: ARP 101, Proteases, Inhibitor Of MMP-2, ARP101, Tocris Bioscience
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    Product Feature
    MMP Inhibitors
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