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Category:
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Enzymes ProteasesMMP
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Cat.No.
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Product Name
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2621 |
ARP 100
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Price and Availability
Click here for full price details of
ARP 100
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Chemical Name:
2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino
]-N-hydroxyacetamide |
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Biological Activity:
Selective inhibitor of MMP-2 (IC50 =
12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC50
values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits
anti-invasive properties in HT1080 fibrosarcoma cells.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Rossello et al
(2004) New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as
selective inhibitors of gelatinase A (MMP-2). Bioorg.Med.Chem. 12
2441. Tuccinardi et al (2006) Amber force field implementation,
molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)-
and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3
methylbutanamides. Bioorg.Med.Chem. 14 4260.
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View related products by Pharmacological Action
or by Research Area
Keywords: ARP 100, Proteases, Selective Inhibitor Of MMP-2, ARP100, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Product Feature
MMP Inhibitors
Key MMP Inhibitors available from Tocris include:
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