|
Category:
|
7TM Receptors Peptides (Gastrointestinal)Galanin Receptors
|
|
Cat.No.
|
Product Name
|
|
2699 |
AR-M 1896
|
| Alternative name(s): |
Gal(2-11)amide |
|
|
Price and Availability
Click here for full price details of
AR-M 1896
|
|
|
|
|
Biological Activity:
Selective galanin GalR2 receptor agonist (IC50
values are 1.76 and 879 nM for GalR2 and GalR1 respectively). Also shows
moderate affinity for GalR3 receptors (Ki values are 88 and 271 nM
for GalR2 and GalR3 respectively). Antiepileptogenic agent; prevents full
seizures and postkindling increases in hippocampal excitability.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
|
References:
Liu et al (2001) Receptor
subtype-specific pronociceptive and analgesic actions of galanin in the spinal
cord: selective actions via GalR1 and GalR2 receptors. Proc.Natl.Acad.Sci USA 98
9960. Lu et al (2005) Galanin (2-11) binds to GalR3 in
transfected cell lines: limitations for pharmacological definition of receptor
subtypes. Neuropeptides 39 165. Mazarati et al
(2006) Regulation of kindling epileptogenesis by hippocampal galanin type 1 and
type 2 receptors: the effects of subtype-selective agonists and the role of
G-protein-mediated signaling. J.Pharmacol.Exp.Ther. 318 700.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: AR-M 1896, Peptides (Gastrointestinal), Selective GalR2 Agonist, Gal(2-11)amide, ARM 1896, Tocris Bioscience
|
|
Purity To Rely On
When choosing reagents for an experiment, the prime consideration is often to obtain the highest quality products available.
Unlike other suppliers, our in-house QC team carry out multiple analytical tests to thoroughly assess the purity of our reagents before they are offered for sale.
This accurate purity data is available on a batch-specific basis for every product via our website. At Tocris we work hard to ensure that we always supply to the highest possible standards of purity.
|
|
