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Category: EnzymesarrowKinasesarrowProtein Kinase B/Akt
Cat.No. Product Name
2151 API-2
Alternative name(s): Triciribine
NSC 154020
TCN
Price and Availability

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API-2
Chemical Name: 1,5-Dihydro-5-methyl-1-b-D-ribofuranosyl-1,4,5,6,8-pent aazaacenaphthylen-3-amine

Biological Activity:

Selective inhibitor of Akt (protein kinase B) signalling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumours. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.

Technical Data:

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M.Wt: 320.31
Formula: C13H16N6O4
Storage: Store at RT
Solubility: Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
CAS No: [35943-35-2]

Resources:

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    References:

    Wotring et al (1990) Dual mechanisms of inhibition of DNA synthesis by triciribine. Cancer Res. 50 4891. Ptak et al (1998) Phosphorylation of triciribine is necessary for activity against HIV type 1. AIDS Res.Hum.Retroviruses. 14 1315. Yang et al (2004) Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumour activity in cancer cells overexpressing Akt. Cancer Res. 64 4394.
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    Keywords: API-2, Kinases, Selective Inhibitor Of Akt / PKB Signalling. Antitumour & Antiviral, Triciribine, NSC 154020, TCN, API2, Tocris Bioscience
    Literature in this Area
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    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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