A functional and membrane permeable Δ-myo-inositol
1,4,5-trisphosphate (IP3) receptor antagonist. Directly inhibits
store-operated calcium entry in human platelets. Modulator of TRP channels,
blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at
higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific
Gap channel subtypes.
Maruyamaet
al (1997) 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable
modulator of Ins(1,4,5)P3-induced Ca2+ release.
J.Biochem. 122 498. Dobrydneva and Blackmore (2001)
2-aminoethoxydiphenyl borate directly inhibits store-operated calcium entry in
human platelets. Mol.Pharmacol. 3 541. Xuet al
(2005) Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential,
extracellular and voltafe-dependent effect. Br.J.Pharmacol. 145
405. Baiet al (2006) Block of specific gap junction channel
subtypes by 2-aminoethoxydiphenyl borate (2-APB). J.Pharmacol.Exp.Ther. 319
1452.
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