AM 114 | Proteases | 20S Proteasome Inhibitor | AM114

Category:

Cat.No.	Product Name
2564	AM 114

Price and Availability

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AM 114

Other Information:

Sold with the permission of Johns Hopkins University

Chemical Name: 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one

Biological Activity:

Inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC₅₀ ~ 1 μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC₅₀ = 1.49 μM).

Technical Data:

M.Wt:	377.01
Formula:	C₂₀H₂₁B₂NO₅
Storage:	Store at +4°C
Solubility:	Soluble to 10 mM in DMSO
Purity:	>98%

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Achanta et al (2005) Preferential killing of cancer cells with wild-type p53 by boronic chalcones. Proc.Am.Assoc.Cancer Res. Abstr. 46 6162. Achanta et al (2006) A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome. Mol.Pharmacol. 70 426.

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Keywords: AM 114, Proteases, 20S Proteasome Inhibitor, AM114, Tocris Bioscience

Literature in this Area

Signal Transduction Guide

	A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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Product Feature

Proteasome and NF-κB

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