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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowAMPA SelectivearrowAgonists
Cat.No. Product Name
0254 (S)-AMPA  
Price and Availability

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(S)-AMPA
Chemical Name: (S)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

Biological Activity:

Active enantiomer of AMPA (EC50 = 3.5 μM).

Technical Data:

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M.Wt: 186.17
Formula: C7H10N2O4
Storage: Store at RT
Solubility: Soluble to 100 mM in Water
Purity: >99%
CAS No: [83643-88-3]

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    References:

    Hansen et al (1983) Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. J.Med.Chem. 26 901. Lauridsen et al (1985) Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors. J.Med.Chem. 28 668. Falch et al (1998) Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships. J.Med.Chem. 41 2513.
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    Keywords: (S)-AMPA, Ligand-gated Ion Channels, Selective AMPA Agonist. Active Isomer, AMPA, Tocris Bioscience
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