AMN 082 | Glutamate (Metabotropic) Receptors | The First Selective MGlu7 Agonist | AMN082

Category:

Cat.No.	Product Name
2385	AMN 082 dihydrochloride

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AMN 082

Chemical Name: N,N'-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride

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Biological Activity:

The first selective mGlu₇ agonist. Potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu₇ (EC₅₀ = 64-290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μM. Acts via a novel allosteric site and is orally active and brain penetrant.

Technical Data:

M.Wt:	465.45
Formula:	C₂₈H₂₈N₂.2HCl
Storage:	Desiccate at +4°C
Solubility:	Soluble to 10 mM in Water and to 100 mM in DMSO and to 10 mM in Methanol
Purity:	>99%
CAS No:	[83027-13-8]

Resources:

Certificate of Analysis / MSDS:

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Product/Material Safety Data Sheet: View current batch

References:

Flor et al (2005) AMN082, the first selective mGluR7 agonist: activation of receptor signaling via an allosteric site in the transmembrane domain modulates stress parameters in vivo. Neuropharmacology 49 (Suppl. 1) 244. Mitsukawa et al (2005) A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc.Natl.Acad.Sci.USA 102 18712.

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Keywords: AMN 082, Glutamate (Metabotropic) Receptors, The First Selective MGlu7 Agonist, AMN082, Tocris Bioscience

Literature in this Area

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Metabotropic Glutamate Receptors
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