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Category:
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Ion Channels Transient Receptor Potential ChannelsTRPV
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Cat.No.
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Product Name
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2316 |
AMG 9810
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Price and Availability
Click here for full price details of
AMG 9810
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Chemical Name:
(2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dim
ethylethyl)phenyl]-2-propenamide |
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Biological Activity:
Potent and selective, competitive vanilloid
TRPV1 receptor antagonist (IC50 = 17 nM). Inhibits capsaicin-,
proton-, heat- and endogenous ligand-induced activation of human and rat
recombinant TRPV1 receptors. Displays antihyperalgesic properties in a rat
model of inflammatory pain.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Doherty et al
(2005) Discovery of potent, orally available vanilloid receptor-1 antagonists.
Structure-activity relationship of N-aryl cinnamides. J.Med.Chem. 48
71. Gavva et al (2005) AMG 9810 [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide],
a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic
properties. J.Pharmacol.Exp.Ther. 313 474.
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or by Research Area
Keywords: AMG 9810, Transient Receptor Potential Channels, Potent & Selective, Competitive Antagonist Of TRPV1, AMG9810, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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