Chemical Name:(RS)-1-Aminoindan-1,5-dicarboxylic acid
Biological Activity:
A relatively potent and selective
antagonist of group I metabotropic glutamate receptors (mGlu1a),
having no effect on group II (mGlu2) or group III (mGlu4)
receptors expressed individually in baby hamster kidney cells. Has no effect on
ionotropic glutamate receptors. Centrally active following systemic
administration in vivo.
Pellicciariet al (1995) 1-Aminoindan-1,5-dicarboxylic acid: a
novel antagonist at phospholipase C-linked metabotropic glutamate receptors.
J.Med.Chem.38 3717. Nielsenet al (1997) Class I
mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual
but not cue conditioning in rats. Eur. J. Pharmacol. 326 105. Moroniet al (1997) Pharmacological characterization of
1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist.
J.Pharmacol.Exp.Ther. 281 721
