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Category:
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Enzyme-Linked Receptors Receptor Tyrosine Kinases (RTKs)EGFR
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Cat.No.
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Product Name
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0497 |
AG 99
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Price and Availability
Click here for full price details of
AG 99
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Chemical Name:
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenamide |
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Biological Activity:
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50
= 10 μM). Selective over
insulin receptor kinase.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Yaish et al (1988) Blocking of EGF-dependent cell proliferation by EGF
receptor kinase inhibitors. Science 242 933. Gazit et
al (1989) Tyrphostins. I. Synthesis and biological activity of protein
tyrosine kinase inhibitors. J.Med.Chem. 32 2344. Levitzki and
Gilon (1991) Tyrphostins as molecular tools and potential antiproliferative
drugs. TiPS 12 171. Gazit (1996) Tyrphostins. 6. Dimeric
benzylidenemalononitrile tyrphostins: potent inhibitors of EGF receptor
tyrosine kinase in vitro. J.Med.Chem. 39 4905.
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View related products by Pharmacological Action
or by Research Area
Keywords: AG 99, Receptor Tyrosine Kinases (RTKs), EGFR-kinase Inhibitor, AG99, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Product Feature
Kinase Inhibitors
Key kinase Inhibitors available from Tocris include:
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