Category:
Enzyme-Linked Receptors Receptor Tyrosine Kinases (RTKs) EGFR
Cat.No.
Product Name
0619
AG 494
Price and Availability Click here for full price details of
Chemical Name:
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenam
ide
Biological Activity:
Potent inhibitor of
epidermal growth factor receptor (EGFR) kinase (IC50 = 0.7 μ M). Selective over Her2-neu, PDGFR and insulin receptor
kinase (IC50 values are 42, 6 and > 100 μ M respectively).
Technical Data:
Resources:
Certificate of Analysis / MSDS:
For specific/earlier batch please select: 1
References:
Gazit et al (1991) Tyrphostins. 2. Heterocyclic and -substituted
benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and
ErbB2/neu tyrosine kinases. J.Med.Chem. 34 Ben-Bassat
et al (1999) Tyrphostins that suppress the growth of human papilloma
virus 16-immortalized human keratinocytes. J.Pharmacol.Exp.Ther. 290
References:
References:
View related products by Pharmacological Action
or by Research Area
Keywords: AG 494, Receptor Tyrosine Kinases (RTKs), Potent EGFR-kinase Inhibitor, AG494, Tocris Bioscience
Literature in this Area
Cancer Research Guide Our unique collection of more than 300 products related to cancer research, including the very latest exclusive research tools. Request Copy / View PDF
Product Feature
Kinase Inhibitors
Key kinase Inhibitors available from Tocris include:
