AG 490 | Receptor Tyrosine Kinases (RTKs) | EGFR-kinase Inhibitor. Also Jak2, Jak3 Inhibitor | Tyrphostin AG 490 | AG490

Category:

Enzyme-Linked Receptors

Receptor Tyrosine Kinases (RTKs)

EGFR

Cat.No.

Product Name

0414

AG 490

Alternative name(s):

Tyrphostin AG 490

AG 490
C17H14N2O3 (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide

Price and Availability

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AG 490

Chemical Name: (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-pr openamide

Biological Activity:

Selective inhibitor of EGF receptor tyrosine kinase (IC₅₀ values are 2 and 13.5 μM for EGFR and Her2-neu respectively). Inhibitor of Jak2, Jak3/STAT, Jak3/AP-1 and Jak3/MAPK pathways.

Technical Data:

M.Wt:	294.31
Formula:	C₁₇H₁₄N₂O₃
Storage:	Store at RT
Solubility:	Soluble to 20 mM in Ethanol and to 100 mM in DMSO
Purity:	>99%
CAS No:	[133550-30-8]

Resources:

Certificate of Analysis / MSDS:

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References:

Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896. Meydan et al (1996) Inhbition of acute lymphoblastic leukaemia by a JAK-2 inhibitor. Nature 379 645. Wang et al (1999) JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response. J.Immunol. 162 3897.

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Keywords: AG 490, Receptor Tyrosine Kinases (RTKs), EGFR-kinase Inhibitor. Also Jak2, Jak3 Inhibitor, Tyrphostin AG 490, AG490, Tocris Bioscience

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