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AC 7954, (±)-
Chemical Name:(±)-3-(4-Chlorophenyl)-3-[2-(dimethylamino)ethyl]-3,4-d
ihydro-1H-2-benzopyran-1-one hydrochloride
Biological Activity:
Highly
selective, non-peptide urotensin II (UT) receptor agonist that displays potent
activity at human and rat UT receptors (pEC50 values are 6.5 and 6.7
respectively).
Crostonet al
(2002) Discovery of the first nonpeptide agonist of the GPR14/urotensin-II
receptor: 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one
(AC-7954). J.Med.Chem. 45 4950. Lavecchiaet al
(2005) Architecture of the human urotensin II receptor: comparison of the
binding domains of peptide and non-peptide urotensin II agonists. J.Med.Chem. 48
2480. Lehmannet al (2006) Novel potent and efficacious
nonpeptidic urotensin II receptor agonists. J.Med.Chem. 49 2232.
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